Engaging patients, healthcare providers, and learners in healthcare presents enduring challenges that require innovative solutions. Gamification and immersive technologies have emerged as transformative approaches that convert routine health tasks into interactive, rewarding experiences (Deterding et al., 2011; Ryan & Deci, 2000). By incorporating game design elements—such as points, badges, challenges, and leaderboards—into healthcare applications, these digital interventions tap into intrinsic motivation to drive behavior change and improve clinical outcomes (Baranowski et al., 2008). Simultaneously, immersive technologies including virtual reality (VR) and augmented reality (AR) offer realistic simulations and enriched environments that facilitate experiential learning, therapeutic distraction, and deeper understanding of complex procedures. Grounded in established behavioral theories, such as Self-Determination Theory and the concept of flow, these strategies empower patients to take active roles in managing their health while enabling clinicians and educators to deliver engaging training experiences. This chapter explores the theoretical foundations underlying gamification and immersive technologies in healthcare, examines diverse practical applications ranging from chronic disease management and rehabilitation to medical education and surgical training, and discusses ethical considerations and future directions. Through detailed case studies and real-world examples, we illustrate how gamified interventions can enhance patient adherence, increase physical activity, and reduce anxiety during treatment, while immersive simulations offer safe, realistic platforms for medical training and patient education. By integrating digital innovation with patient-centered care, gamification and immersive technologies promise to redefine the healthcare experience, making it more interactive, personalized, and effective.